–едакци€ портала
28 феврал€ 2014, 21:55 567 +2

ѕоликистоз почек 

√руппа заболеваний: болезни почек и мочевых путей
¬рач в каталоге: уролог
ѕораженный орган: почка
 

‘акторы риска

  • ѕоликистоз почек в семейном анамнезе
  • ƒругие заболевани€ почек
  • ƒлительный диализ

ќписание

ѕоликистоз почек (синоним: поликистозна€ болезнь почек, сокр. ѕЅѕ) - одна из наиболее т€жЄлых аномалий, характеризующихс€ замещением значительной части почечной паренхимы множественными кистами различных форм и размеров. —о временем количество кист растет, они повреждают почечную ткань, наруша€ нормальную работу почек и привод€ к почечной недостаточности.  исты содержат вод€нистую (иногда желеобразную) желтоватую, с примесью крови и гно€ жидкость.

ѕо частоте возниковени€ аномали€ уступает только простым кистам, а по т€жести клинического течени€ и числу осложнений занимает первое место среди всех почечных болезней. ѕоликистоз почек, по данным литературы, среди почечных заболеваний составл€ет от 0,17 до 16,5%.

ѕоликистоз почек относ€т к врождЄнным наследственным заболевани€м мочевывод€щих путей. Ѕолезнь затрагивает не только сами почки, но часто также другие органы (печень). ѕочки увеличиваютс€ при уменьшении функционирующей паренхимы.  исты представл€ют собой расширенные части почечных клубочков и канальцев, сохран€€ св€зь с оставшейс€ частью нефрона.

 лассификаци€ поликистоза почек

ћногие авторы с учетом морфологических особенностей и клинического течени€ поликистоза почек различают:

  • поликистоз новорождЄнных;
  • поликистоз детей;
  • поликистоз подростков;
  • поликистоз взрослых. 

”глублЄнный клинико-генетический и морфологический анализ показал, что несмотр€ на значительные различи€ между поликистозом почек новорождЄнных, детей и подростков, это патологическое состо€ние по существу едино. ƒл€ поликистоза детского возраста характерен аутосомно-рецессивный тип наследовани€ заболевани€, но мутаци€ происходит в разных генах. (јутсомный - т.е. деффектный ген не св€зан с полом).

“аким образом более верно различать два вида поликистоза:

  • аутосомно-доминантную болезнь поликистоз почек у взрослых (про€вл€етс€  30-40 лет); 
  • аутосомно-рецессивную болезнь поликистоз почек у детей (про€вл€етс€ в раннем детстве). 

ѕричины

јутосомно-рецессивна€ поликистозна€ болезнь почек св€зана с мутацией гена PKHD1, который кодирует белок фиброцистин.

јутосомно-доминантна€ поликистозна€ болезнь почек встречаетс€ в человеческой попул€ции с частотой 1/400 — 1/1000, €вл€€сь одной из наиболее распространЄнных генетических болезней. ќбщее количество больных в мире оцениваетс€ в 10-12 млн человек. 85 % случаев аутосомно-доминантного поликистоза почек вызваны мутациeй гена PKD1, локализованном в регионе 16p13.3 и кодирующем белок полицистин-1 (в этом случае средний возраст развити€ терминальной почечной недостаточности составл€ет 54 года), 15 % случаев св€заны с мутацией гена PKD2 в регионе 4q21 и кодирующем белок полицистин-2 (средний возраст развити€ терминальной почечной недостаточности составл€ет 74 года).

јутосомно-доминантна€ поликистозна€ болезнь почек в 90 % случаев наследуетс€ от родителей, тогда как примерно в 10 % случаев €вл€етс€ результатом спонтанных мутаций гена.

јутосомно-доминантна€ и аутосомно-рецессивна€ поликистозна€ болезнь почек относитс€ к цилиопати€м - группе заболеваний, дл€ которых характерно нарушение нормальной работы ресничек на поверхности р€да клеток, за счет которых обеспечиваетс€ «прием» сигналов из внеклеточной среды. Ѕелки полицистин-1, полицистин-2 и фиброцистин вход€т в состав первичных ресничек на поверхности клеток млекопитающих. ¬ клетках эпители€ почечных канальцев первичные реснички располагаютс€ со стороны просвета почечных канальцев, и предполагаетс€, что это обеспечивает их сенсорную функцию - чувствительность к току мочи. ¬ результате неправильного воспри€ти€ сигналов из-за нарушенной работы первичных ресничек в клетках почечного эпители€ происходит накопление циклического аденозинмонофосфата, на снижение уровн€ которого направлено действие р€да экспериментальных методик лечени€ поликистоза почек.

ѕоликистоз почек взрослых встречаетс€ у одного из 1000 человек, медленно прогрессирует. —редн€€ продолжительность жизни при этом заболевании - 50 лет. ѕро€влени€ болезни начинаютс€ в молодом или среднем возрасте, и около 10 лет она остаЄтс€ компенсированной. ¬ этой стадии болезни возможно оперативное лечение заключающеес€ во вскрытии кистозных образований путЄм резекции их купола. ¬ последние годы примен€ют пункцию под ультразвуковым контролем наиболее крупных кист, а также кист значительно нарушающих кровоток. ѕримерно у трети больных вы€вл€ют кисты печени, что не имеет функциональных последствий.

Ќа макроуровне дл€ поликистоза характерно наличие множественных кист (отсюда название: поли- + киста + -оз) в обеих почках.  исты образуютс€ из-за повышенной пролиферации и дедифференциации эпители€ канальцев нефрона. ¬ результате вместо нормальных почечных канальцев образуютс€ наполненные жидкостью пузырьки - кисты, что приводит к значительному увеличению объема почек (вес почки больного может достигать 35 кг).  исты в почке больного возникают фокально, не более чем в 2-5 % нефронов, но из-за увеличени€ объЄма кист происходит сдавление соседних здоровых нефронов, и постепенно почка тер€ет фильтрующую функцию.

 роме того, поскольку первичные реснички имеютс€ в клетках других органов, при поликистозе почек также часто развиваютс€ кисты в печени, поджелудочной железе, в сосудах головного мозга.

 ак развиваетс€ болезнь

” новорождЄнных поликистозные почки равномерно увеличены, сохран€етс€ их эмбриональна€ дольчатость. Ќа разрезе почки кисты имеют одинаковую величину и форму, локально рассе€ны среди нормальной паренхимы, корковый и мозговой слои чЄтко не разграничены. ” детей старшего возраста и подростков морфологическа€ картина поликистоза отличаетс€ тем, что в патологический процесс вовлечено уже свыше 25% канальцев. ѕочки значительно увеличены, поверхность бугриста€. „ерез фиброзную капсулу просвечивают кисты. Ќа разрезе среди тускловатой почечной паренхимы разбросано множество кист уже не одинаковой величины, как у новорождЄнных, а разной, хот€ они меньше, чем у взрослых. ѕросвет канальцев расширен, местами сдавлен, нефроны недоразвиты.

” взрослых количество неизменЄнной паренхимы значительно уменьшаетс€. ∆идкость в кистах прозрачна€, при воспалении - гнойна€, при кровоизли€ни€х окрашиваетс€ в бурый цвет. —одержимое кист отличаетс€ от плазмы по составу основных электролитов и состоит из мочевины, мочевой кислоты, холестерина. Ќа разрезе почек их поверхность усе€на кистами различного диаметра.  ак правило большие кисты чередуютс€ с мелкими, разбросаны по всей паренхиме почки, напомина€ пчелиные соты неправильной формы.

¬ зависимости от давности процесса и степени вторичных осложнении паренхима приобретает сероватый оттенок, а еЄ функциональна€ способность прогрессивно уменьшаетс€.

ћикроскопическое исследование неосложненных кист показывает, что их внутренн€€ поверхность выстлана кубическим эпителием. —тенки кист состо€т из тонкого сло€ плотной соединительной ткани, пронизанной мелкими безм€котными нервными пучками, распростран€ющимис€ в недоразвитых гладких мышцах.  оличество нервных структур значительно уменьшаетс€ при присоединении инфекции. √ибель нервных элементов в поликистозной почке обусловлена аноксией на почве ишемии почечной ткани.

—имптомы

ѕоликистоз почек имеет разнообразные симптомы. ќни завис€т от возраста больного, количества и величины кист, сохранности паренхимы органа. ѕро€влени€ поликистоза почек св€заны либо с самими кистами, либо с про€влени€ми почечной недостаточности.

Ќаиболее частые симптомы поликистоза почек:

  • артериальна€ гипертензи€ у 50% пациентов;
  • тупа€ ноюща€ боль в по€сничной области;
  • гематури€;
  • пиури€;
  • сердечно-сосудистые расстройства;
  • макрогематури€;
  • пальпируемые увеличенные почки;
  • жажда;
  • полиури€.

Ѕоль в по€сничной области в 40-70% случаев по€вл€етс€ сравнительно рано, а с возрастом еЄ отмечают у 90% больных. ” подавл€ющего большинства пациентов она носит непосто€нный, перемежающийс€ характер. »нтенсивность боли зависит от степени нарушени€ уродинамики и микроциркул€ции в почке и от выраженности пиелонефрита.

Ѕоль в эпигастральной области возникает от давлени€ увеличенных почек на внутрибрюшные органы и от нат€жени€ св€зочного аппарата почек.

ƒиспепсические расстройства в сочетании с болью нередко ошибочно принимают за острые желудочно-кишечные заболевани€, что иногда служит поводом дл€ неоправданной срочной лапаротомии. —ердечно-сосудистые расстройства про€вл€ютс€ болью в области сердца, головной болью, головокружением.

” 70-75% больных с поликистозом почек наблюдают симптоматическую артериальную гипертензию с высоким диастолическим артериальным давлением (свыше 110 мм. рт. ст.) то есть у большинства больных артериальной гипертензии носит злокачественный характер. —тепень выраженности гипертензии зависит от ишемизации почечной ткани в результате сдавлени€ кистами паренхимы почки, что ведет к ее атрофии и повышению внутрипочечного давлени€.  роме того, развивающийс€ пиелонефрит с последующим асимметричным замещением паренхимы почек соединительной тканью усугубл€ет дисфункцию почек. ” 70-75% больных при исследовании глазного дна определ€ют ретинопатию.

∆ажду и полиурию наблюдают как симптомы хронической почечной недостаточности различных стадий. ¬ жаркое врем€ года больные с поликистозом почек выпивают до 3-4 л жидкости и выдел€ют до 2-2.5 л в сутки. ∆ажда и полиури€ характеризуют нарушенную концентрационную способность почек.

ћакрогематурию как симптом поликистоза почек вы€вл€ют у 30-50% больных, часто она бывает кратковременной, тотальной и, как правило, не сопровождаетс€ угрожающей жизни анемизацией организма. »сточником кровотечени€ чаще служат форниксы, в которых развиваютс€ застойные процессы, привод€щие к папиллиту. ” большинства больных макрогематурию удаетс€ ликвидировать противовоспалительной терапией, гемостатическими препаратами, покоем. ¬ редких случа€х, при значительной гематурии, приходитс€ выполн€ть оперативное вмешательство.

ѕочки при поликистозе увеличиваютс€ у 70-80% больных, которые нередко сами прощупывают увеличенные почки. „асто встречают подвижные поликистозные почки, которые легко пальпируютс€ через переднюю брюшную стенку, имеют бугристую, иногда болезненную, поверхность.

ƒиагностика

ƒиагностика поликистоза почек базируетс€ на анамнезе, об€зательно включающем изучение генеалогической линии, что нередко позвол€ет установить наследственную природу заболеваний.

ѕри осмотре больного следует обратить внимание на сухость и некоторую желтушность кожи, расчЄсы вследствие кожного зуда. ѕри пальпации брюшной полости прощупываютс€ почки в виде больших, плотных, бугристых образований. »ногда поликистозные почни настолько выбухают из подреберий, что мот определ€тьс€ визуально.

ƒл€ оценки функционального состо€ни€ поликистозных почек определ€ют концентрацию мочевины и креатинина в сыворотке крови, провод€т анализ мочи по «имницкому, пробу –еберга.

ѕри исследовании мочи обнаруживают:

  • гипоизостенурию (относительна€ плотность мочи от 1.005 до 1.010), что указывает на поражение канальцевого аппарата почек;
  • протеинурию (не выше 1 г/л):
  • лейкоцитурию, указывающую на присоединение мочевой инфекции.

ѕри исследовании крови часто вы€вл€ют:

  • гипохромную анемию;
  • при пиелонефрите - умеренный неитрофильный лейкоцитоз со сдвигом лейкоцитарной формулы влево. 

ƒиагностика поликистоза почек возможна с помощью следующих методов исследовани€:

  • рентгенологические методы (экскреторна€ урографи€, ретроградна€ пиелографи€);
  • радионуклеидные методы (динамическа€ сцинтиграфи€, ренографи€);
  • ”«» с допплерографией;
  •  “ (почечна€ ангиографи€);
  • более точно диагноз устанавливают с помощью ћ— “ и ћ–“.

–ешающую роль в диагностике поликистоза почек играют рентгенологические методы исследовани€. Ќа обзорных рентгенограммах удаЄтс€ обнаружить вертикальную локализацию обеих почек, более медиальное и низкое расположение их теней, незначительную подвижность почек. «начительно чЄтче эти признаки вы€вл€ют на фоне пресакрального ретропневмоперитонеума, но в насто€щее врем€ он практически утратил своЄ диагностическое значение, так как ”«»,  “ и ћ–“ позвол€ют чЄтко определить данную аномалию.

Ёкскреторна€ урографи€ позвол€ет получить ценные данные в начальных стади€х заболевани€. ѕоскольку поликистоз сопровождаетс€ снижением функции почек, целесообразно проводить еЄ инфузионную модификацию. Ќ.ј. Ћопаткин и ј.¬. Ћюлько (1987) выделили три рентгенологических признака:

  • изменение очертаний почек (низкое расположение, увеличение в длину и ширину, неровный контур);
  • изменение лоханки и чашечек (деформаци€ осей больших и малых чашечек, их полулуние, сферическое и колбовидное изменение, сужение и удлинение шеек, удлинение и смещение лоханки);
  • изменение сосудистой системы почек (сужение крупных артериальных стволов и уменьшение количества мелких артерий, наличие разнокалиберных аваскул€рных полей).

  этому следует добавить, что при поликистозе всегда увеличено число чашечек - гиперрамификаци€, сдавление, удлинение, смещение и опущение лоханки. Ћћ— обычно смещЄн в медиальную сторону, а лоханка имеет внутрипочечное расположение.

 роме того, дл€ уточнени€ диагноза поликистоза почек примен€ют радионуклидные методы исследовани€, ультразвуковое сканирование,  “.

Ќа ренограммах, выполненных у больных поликистозом, Ќ.ј. Ћопаткин, ё.я. и ≈.Ѕ. ћазо (1977) выделили три варианта:

  • двустороннее замедление секреции и эвакуации;
  • преимущественное поражение одной почки при сохранЄнной еЄ функции;
  • поражение канальцевого аппарата одной и отсутствие функции второй поликистозной почки, что наблюдаетс€ при т€жЄлой форме поликистоза. когда наступает атрофи€ паренхимы одной из почек вследствие компрессии еЄ кистами.

 ак правило, эти больные имеют разную степень выраженности почечной недостаточности. –енографи€ служит ориентирующим тестом, так как она даже косвенно не даЄт ответа на вопрос о количестве функционирующей паренхимы. ƒинамическа€ сцинтиграфи€ восполн€ет перечисленные недостатки ренографии.

”«» позвол€ет диагностировать поликистоз почек по большому количеству эхонегативных зон. ¬ ранней стадии поликистоза почек ультрасонографи€ вы€вл€ет их увеличение. ≈сли этот порок развити€ прогрессирует, в паренхиме почек обычно обнаруживают кисты различной величины и формы. ”«» в сочетании с допплерографией позвол€ет не только вы€вить заболевание, но и уточнить состо€ние почечного кровотока.

јбсолютно достоверна диагностика поликистоза почек методом  “. »ногда дл€ уточнени€ диагноза необходимо проведение почечной ангиографии. ѕри поликистозе почек на ангиограммах (особенно важна паренхиматозна€ фаза) определ€ют дефекты насыщени€, почечные сосуды сужены, количество мелких артерий уменьшено. ќпредел€ют пол€ без сосудов, соответствующие кистам.

ћ— “ и ћ–“ способны не только обнаружить сами кистозные образовани€, представить внутрипочечные взаимоотношени€, оценить ширину и прот€жЄнность шейки, но и определить характер их содержимого, помога€ дифференциальной диагностики нагноени€ кист с деструкцией паренхимы. ѕолученна€ информаци€ может быть полезна при выборе тактики лечени€. 

Ћечение

Ѕольные поликистозом почек нуждаютс€ в длительном лечении с назначением периодически повтор€ющихс€ курсов медикаментозной терапии и в посто€нном соблюдении диетического режима. Ћечение поликистоза почек направлено на ликвидацию или ослабление пиелонефрита, улучшение и сохранение функции почек.

ћедикаметозное лечение поликистоза почек

ѕоказано антибактериальное лечение поликистоза почек, так как этому пороку развити€ практически всегда сопутствует инфекци€ - пиелонефрит.

¬ыбор антибиотика и химиотерапевтического препарата зависит прежде всего от результата определени€ чувствительности к ним выделенных штаммов микроорганизмов. —ледует особо учитывать нефротоксичность препаратов и опасность их кумул€ции в организме. Ћечение должно быть длительным; об его эффективности можно судить только тогда, когда два культуральных исследовани€ мочи дали отрицательный результат, улучшились функциональные пробы почек, нормализовались показатели крови и —ќЁ.

√ипертензивные средства назначают по обычной схеме. ¬ лечении гипертензии следует стремитьс€ к увеличению выделени€ солей с мочой или уменьшению поступлени€ натри€ в организм.

ѕоликистоз почек: лечение хирургическими методами

ѕоказани€ к оперативному лечению поликистоза почек индивидуальны; как правило, они строго регламентированы и направлены на ликвидацию осложнений. ¬се виды операций при поликистозе нос€т паллиативный характер. ќперативное лечение поликистоза почек провод€т при выраженных бол€х, затрудн€ющих обычную жизнь больных. при нагноении кист, при тотальной угрожающей жизни гематурии, при гипертензии. не поддающейс€ гипотензивной терапии, при больших кистах, сдавливающих магистральные сосуды почки и Ћћ—, при злокачественных перерождени€х кистозной почки, при больших камн€х в лоханке или окклюзирующих в мочеточнике.

Ќаиболее распространЄнной операцией при поликистозе почек остаЄтс€ оперативна€ декомпресси€, предложенна€ в 1911 году –овзингом; этот метод получил название игнипунктуры. ѕоказани€ к ней должны строитьс€ с учЄтом возраста, характера заболевани€, степени выраженности осложнений и эффективности консервативной терапии. »гнипунктура позвол€ет достичь длительного положительного эффекта, если она выполн€етс€ в стадии компенсации у больных в возрасте 30-50 лет. ќперативна€ декомпресси€ уменьшает размеры кист, снимает боль, снижает внутрипочечное давление, улучшает микроциркул€цию в почке и функции нефронов. —торонником этой операции был —ѕ. ‘Єдоров (1923), он первым предложил и выполнил после пункции кист окутывание почки большим сальником (оментонефропекси€), что в дальнейшем примен€л ћ.ƒ. ƒжавад-«аде, однако восстановлени€ функций почек не наступало.

¬ 1961 г. был разработан и внедрЄн в клиническую практику более простое и безопасное лечение поликистоза почек - чрескожна€ пункци€ кист. ѕункци€ максимально возможного количества кист при поликистозе почек позвол€ет получить без т€жЄлой травмы, обусловленной оперативным вмешательством, результат, близкий к результату, достигаемому игнипунктурой.

ѕри чрескожной пункции, осуществл€емой под контролем ”«» или  “, риск обширной травматизации почечной ткани весьма незначителен даже при декомпрессии кист, расположенных глубоко в паренхиме почек. „рескожна€ пункци€, выполн€ема€ один раз в 4-6 мес, позвол€ет длительно поддерживать основные обменные функции почек у больных поликистозом в состо€нии компенсации. ѕерманентно выполн€емую чрескожную пункцию кист поликистозных почек можно считать альтернативой открытому оперативному лечению.

ј.¬. Ћюлько рекомендует переводить больных с высокими показател€ми азотемии и креатининемии на программный диализ с последующей трансплантацией почки. ¬ключение больного в программный диализ практически не обеспечивает стойкой ремиссии, и больные либо пожизненно остаютс€ на гемодиализе, либо нуждаютс€ в трансплантации почки.

—очетание поликистозных заболеваний с другими аномали€ми почек

¬ литературе описаны случаи частого сочетани€ поликистоза почек с поликистозом печени, поджелудочной железы и других органов. ќн может сочетатьс€ и с другими аномали€ми самих почек. ѕри этом вы€вл€ютс€ как врождЄнные, так и приобретЄнные, ретенционного характера кисты.

 ак особый редкий случай наблюдали поликистоз подковообразной почки с ретенционными кистами в перешейке.

ƒиета при поликистозе почек

Ќеобходимо адекватное в количественном и качественном отношении питание. ѕри неполноценном питании, прежде всего при недостаточном содержании белка в пище, заболевание протекает т€желее.

—уточную потребность в белке (90-100 г) лучше всего удовлетвор€ют введением в рацион дополнительных белковых продуктов (творог, сн€тое молоко).  оличество жиров и углеводов следует ограничить. Ёффективна диета с ограничением натри€ (максимальное употребление поваренной соли за сутки 3-4 г). —уточна€ энергетическа€ ценность должна составл€ть не менее 3000 ккал. ќсновную часть энергетических затрат следует восполн€ть за счЄт углеводов и растительных жиров; об€зателен приЄм витаминов.

 
–едакци€ портала
28 феврал€ 2014, 21:55
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